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. 2022 May 25;20:189. doi: 10.1186/s12916-022-02391-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Effect of intraperitoneal administration of EZH2 inhibitor on fetoplacental weights in the mouse. A Time-line illustrating experimental procedures in pregnant mice. i.p., intraperitoneal injection. B–G Administration of EZH2 inhibitor EPZ005687 (EPZ) (8 mg/kg BW) increased the average fetal (B) and placental (C) weights per litter (control, n = 9 dams; EPZ, n = 8 dams) as well as the fetal (D and F) and placental (E and G) weights of each sex. Female fetuses: control group, n = 32; EPZ group, n = 29; male fetuses: control group, n = 31; EPZ group, n = 24. Data are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs control group