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. 2022 May 25;20:189. doi: 10.1186/s12916-022-02391-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Effect of intraperitoneal administration of EZH2 inhibitor on placental H3K27me3, ADAM12, Hsd11b2 abundance, and maternal blood ADAM12-S level in the mouse. A EPZ administration (8 mg/kg BW) decreased the abundance of placental H3K27me3 (control group, n = 24; EPZ group, n = 24). Top panel is the representative immunoblot. B, C EPZ administration (8 mg/kg BW) increased the abundance of placental Adam12s and Hsd11b2 mRNA (control group, n = 63; EPZ group, n = 53). D EPZ administration (8 mg/kg BW) increased ADAM12-S level in maternal blood (control group, n = 7; EPZ group, n = 6). Data are means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs control group