Table 9.

List of toxicological studies with the NF (as component of the mixture of HiMOs)

Reference	Type of study	Test system	Dose
Unpublished Study, LPT No. 35908 (Parschat et al., 2020)	Bacterial reverse mutation test (GLP, OECD TG 471)	Salmonella Typhimurium TA98, TA100, TA102, TA1535 and TA1537	0.8–90 mg 3‐FL/plate (absence and presence of S9 mix)
Unpublished Study, LPT No. 35909 (Parschat et al., 2020)	In vitro mammalian cell micronucleus test in human peripheral blood lymphocytes (GLP, OECD TG 487)	Human peripheral blood lymphocytes	1.2–9.6 mg 3‐FL/mL for 4 or 24 h (absence and presence of S9 mix)
Unpublished study, LPT No. 35504 (Parschat et al., 2020)	7‐day repeated dose oral toxicity study (pilot study)	SD rats (females only)	Dietary exposure ranging from 6.7 to 13.7 g/kg bw/day (mean 3‐FL intake: 1.07–2.19 g/kg bw/day)
Unpublished Study, LPT No. 35907 (Parschat et al., 2020)	90‐day repeated dose oral toxicity study (GLP, OECD TG 408, limit test)	SD rats	Overall dietary exposure to 3‐FL of 16% of the mixture (mean intake of 0.91 and 1.12 g 3‐FL/kg bw/day in males and females, respectively)