Table 3.
Subgroup analysis of the ADCmean value for diagnosis of MVI+ and poorly differentiated HCC.
| Indicators/Subgroup | Groups (Studies) | AUC (95%CI) | Sensitivity (95% CI) | Specificity (95% CI) | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | I2 | |
|---|---|---|---|---|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | ||||||||
| Poorly differentiated HCC | |||||||||
| Study design | Retrospective (n = 13) | 0.87 (0.84, 0.90) | 0.84 (0.76, 0.89) | 0.75 (0.64, 0.84) | 3.3 (2.2, 5.1) | 0.22 (0.14, 0.33) | 15 (7, 32) | 57.32 | 85.14 |
| Prospective (n = 3) | 0.84 (0.80, 0.87) | 0.81 (0.61, 0.92) | 0.78 (0.71, 0.84) | 3.7 (2.8, 4.9) | 0.24 (0.12, 0.51) | 15 (7, 35) | 75.69 | 28.46 | |
| Sample size | >90 (n = 7) | 0.88 (0.85, 0.90) | 0.86 (0.78, 0.91) | 0.73 (0.62, 0.82) | 3.2 (2.3, 4.5) | 0.19 (0.13, 0.29) | 16 (10, 27) | 57.57 | 86.91 |
| ≤90 (n = 9) | 0.85 (0.82, 0.88) | 0.78 (0.65, 0.88) | 0.79 (0.67, 0.87) | 3.7 (2.1, 6.5) | 0.28 (0.15, 0.50) | 13 (5, 39) | 63.23 | 73.56 | |
| Machine type | 3.0T (n = 7) | 0.82 (0.78, 0.85) | 0.81 (0.71, 0.88) | 0.73 (0.66, 0.79) | 3.0 (2.5, 3.6) | 0.26 (0.17, 0.39) | 12 (7, 18) | 74.27 | 59.89 |
| 1.5T (n = 9) | 0.88 (0.85, 0.91) | 0.84 (0.74, 0.91) | 0.79 (0.62, 0.90) | 4.0 (2.0, 8.0) | 0.20 (0.11, 0.37) | 20 (6, 63) | 54.30 | 89.78 | |
| Number of b value | >3 (n = 7) | 0.86 (0.83, 0.89) | 0.78 (0.67, 0.86) | 0.80 (0.70, 0.87) | 3.9 (2.3, 6.4) | 0.27 (0.16, 0.46) | 14 (5, 37) | 62.24 | 70.21 |
| ≤3 (n = 9) | 0.87 (0.84, 0.90) | 0.87 (0.78, 0.93) | 0.71 (0.58, 0.81) | 3.0 (2.1, 4.3) | 0.18 (0.10, 0.31) | 17 (9, 32) | 61.7 | 86.33 | |
| Maximum b value | >800 (n = 9) | 0.81 (0.78, 0.85) | 0.76 (0.68, 0.83) | 0.73 (0.64, 0.81) | 2.8 (2.2, 3.7) | 0.32 (0.25, 0.42) | 9 (6, 13) | 34.64 | 79.08 |
| ≤800 (n = 7) | 0.93 (0.90, 0.95) | 0.91 (0.78, 0.97) | 0.80 (0.63, 0.90) | 4.5 (2.2, 9.1) | 0.11 (0.04, 0.30) | 40 (10, 169) | 78.23 | 87.92 | |
| MVI(+) vs. MVI(-) | |||||||||
| Study design | Retrospective (n = 5) | 0.78 (0.74, 0.81) | 0.73 (0.65, 0.80) | 0.72 (0.57, 0.83) | 2.6 (1.7, 3.9) | 0.38 (0.30, 0.48) | 7 (4, 12) | 34.54 | 85.96 |
| Prospective (n = 3) | 0.77 (0.74, 0.81) | 0.74 (0.64, 0.82) | 0.71 (0.59, 0.81) | 2.6 (1.7, 4.0) | 0.37 (0.25, 0.54) | 7 (3, 15) | 0 | 36.7 | |
| Sample size | >90 (n = 4) | 0.76 (0.72, 0.80) | 0.74 (0.67, 0.81) | 0.63 (0.52, 0.73) | 2.0 (1.6, 2.6) | 0.40 (0.32, 0.51) | 5 (3, 8) | 25.48 | 79.83 |
| ≤90 (n = 4) | 0.81 (0.78, 0.85) | 0.74 (0.64, 0.81) | 0.80 (0.72, 0.87) | 3.8 (2.6, 5.5) | 0.33 (0.24, 0.46) | 11 (6, 21) | 0 | 36.13 | |
| Machine type | 3.0T (n = 5) | 0.77 (0.73, 0.80) | 0.73 (0.65, 0.80) | 0.73 (0.60, 0.83) | 2.7 (1.8, 4.0) | 0.37 (0.28, 0.49) | 7 (4, 13) | 0 | 70.66 |
| 1.5T (n = 3) | 0.78 (0.74, 0.81) | 0.74 (0.65, 0.81) | 0.70 (0.52, 0.83) | 2.4 (1.5, 3.9) | 0.37 (0.28, 0.49) | 7 (3, 12) | 20.9 | 84.49 | |
| Number of b value | >3 (n = 4) | 0.73 (0.69, 0.77) | 0.72 (0.63, 0.79) | 0.76 (0.63, 0.86) | 3.0 (1.9, 4.9) | 0.37 (0.27, 0.51) | 8 (4, 17) | 0 | 68.92 |
| ≤3 (n = 4) | 0.78 (0.74, 0.81) | 0.75 (0.68, 0.81) | 0.67 (0.53, 0.78) | 2.3 (1.6, 3.2) | 0.37 (0.29, 0.47) | 6 (4, 10) | 12.73 | 84.8 | |
| Maximum b value | >800 (n = 5) | 0.74 (0.70, 0.78) | 0.73 (0.65, 0.79) | 0.77 (0.67, 0.84) | 3.1 (2.1, 4.6) | 0.36 (0.27, 0.48) | 9 (5, 16) | 0 | 61.19 |
| ≤800 (n = 3) | 0.77 (0.73, 0.80) | 0.75 (0.67, 0.82) | 0.63 (0.47, 0.76) | 2.0 (1.4, 2.9) | 0.39 (0.30, 0.51) | 5 (3, 9) | 3.42 | 78.99 | |
ADCmean, mean apparent diffusion coefficient; MVI, microvascular invasion; AUC, area under the curve; PLR, positive likelihood ratio; NLR, negative likelihood ratio; DOR, diagnostic odds ratio; HCC, hepatocellular carcinoma.