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. 2022 May 25;20:71. doi: 10.1186/s12964-022-00890-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — DCA activates Wnt signaling pathway and suppressed the G2/M checkpoint. a, b the DEGs of DCA vs control group were displayed by volcano and heat maps. c–e The KEGG, GESA, and Reactome analyses for DEGs. f Gene set enrichment analysis indicated angiogenesis-associated genes was upregulated in DCA group. g The PPI network among DEGs was visualized by Cytoscape and divided all DEGs into 12 MCODE functional modules