Table 2. Multivariable Logistic Regression for Positive Overall Survival Improvement by at Least 2 Months.

Variable	OR (95% CI)	P value
Line of therapy
Second	1.31 (1.24-1.38)	<.001
Third and beyond	0.57 (0.51-0.63)	<.001
First	1 [Reference]	NA
Treatment type
Cytotoxic and other	0.15 (0.13-0.16)	<.001
Cytotoxic and targeted	1.45 (1.38-1.53)	<.001
Other	1.22 (1.07-1.40)	0.004
Targeted	3.08 (2.81-3.37)	<.001
Cytotoxic	1 [Reference]	NA
Study period
1997-2006	0.39 (0.36-0.41)	<.001
2007-2016	0.42 (0.39-0.45)	<.001
1986-1996	1 [Reference]	NA
Placebo
Yes	0.25 (0.24-0.27)	<.001
No	1 [Reference]	NA
Funding source
Pharmaceutical company	0.57 (0.54-0.60)	<.001
Pharmaceutical company and nonprofit organization	0.57 (0.54-0.60)	<.001
Nonprofit organization	1 [Reference]	NA

Abbreviations: NA, not applicable OR, odds ratio.