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. Author manuscript; available in PMC: 2022 May 25.
Published in final edited form as: Science. 2021 Mar 19;371(6535):eabc8433. doi: 10.1126/science.abc8433

Fig 2: Structural basis for IL-10Rβ engagement by IL-10.

Fig 2:

(A, B) Two views of the IL-10–IL-10Rα–IL-10Rβ ternary sub-complex, with IL-10 in green, IL-10Rα in purple, and IL-10Rβ in salmon. (C-E) Close-up views of the IL-10–IL-10Rβ binding interface. Hydrogen bonds and salt-bridges are shown as black dashed-lines. Mutated residues in affinity matured super-10 are italicized. (F) Corresponding views of the IL-10–IL-10Rβ interface and the IFN-λ–IL-10Rβ interface (PDB ID: 5T5W). The IBD-associated residue Glu141 is shown in yellow. (G) Immunoblot of lysates prepared from HEK-293T cells transiently expressing the indicated receptor constructs and stimulated with IL-10 or IFN-λ for 20 min.