Wainstein 2017.
| Study characteristics | |||
| Patient Sampling | Retrospective | ||
| Patient characteristics and setting |
Study location: Argentina Study periods: between June 2010 and June 2016 Care setting: Transplant Center in Buenos Aires, Argentina Participants enrolled: 134: 63 males and 71 females Participants included in analysis: 134: 63 males and 71 females Age: mean age 47 ± 14.7 years BMI: not reported Classification of PH defined by WHO (diagnosis from right‐heart catheterisation): Class I: 0, Class II: 0, Class III: 83, Class IV: 0, Class V: 0 Number of patients with asymptomatic or mild symptom: not reported Number of participants with COPD: 65 Number of intubated participants: 0 Inclusion criteria: The population included all patients who had Doppler echocardiography and right‐heart catheterisation performed within 3 days of each other. Exclusion criteria: not reported |
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| Index tests |
Description of index test: not reported Description of method to estimate right atrial pressure: not reported Cut‐off value to declare PH: 36 mmHg Estimated systolic pulmonary arterial pressure: not reported Sonographer qualification: not reported How to handle the uninterpretable results: not applicable |
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| Target condition and reference standard(s) |
Target condition: pulmonary hypertension Description of reference standard: not reported Mean pulmonary arterial pressure: not reported |
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| Flow and timing | The interval between the index test and reference standard: within 3 days Number of indeterminates for whom the results of reference standard was available: 0 (0%) Number of patients who were excluded from the analysis: 0 (0%) |
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| Comparative | |||
| Notes | |||
| Methodological quality | |||
| Item | Authors' judgement | Risk of bias | Applicability concerns |
| DOMAIN 1: Patient Selection | |||
| Was a consecutive or random sample of patients enrolled? | Yes | ||
| Did the study avoid inappropriate exclusions? | Yes | ||
| Could the selection of patients have introduced bias? | Low risk | ||
| Are there concerns that the included patients and setting do not match the review question? | High | ||
| DOMAIN 2: Index Test (All tests) | |||
| Were the index test results interpreted without knowledge of the results of the reference standard? | Unclear | ||
| If a threshold was used, was it pre‐specified? | Unclear | ||
| Could the conduct or interpretation of the index test have introduced bias? | Unclear risk | ||
| Are there concerns that the index test, its conduct, or interpretation differ from the review question? | Unclear | ||
| DOMAIN 3: Reference Standard | |||
| Were the reference standard results interpreted without knowledge of the results of the index tests? | Unclear | ||
| Were the criteria of reference standard for target condition prespecified? | Unclear | ||
| Could the reference standard, its conduct, or its interpretation have introduced bias? | Unclear risk | ||
| Are there concerns that the target condition as defined by the reference standard does not match the question? | Low concern | ||
| DOMAIN 4: Flow and Timing | |||
| Was the interval between the index test and reference standard less than one day? | No | ||
| Did all patients receive the same reference standard? | Yes | ||
| Were all patients included in the analysis? | Yes | ||
| Could the patient flow have introduced bias? | High risk | ||
BMI: body mass index COPD: chronic obstructive pulmonary disease HIV: human immunodeficiency virus IQR: interquartile range IPH: idiopathic pulmonary hypertension IVC: inferior vena cava PA: pulmonary artery PCW: pulmonary capillary wedge PH: pulmonary hypertension PP: pulmonary pressure PVR: pulmonary vascular resistance RA: right atrium RAPmean: mean right atrial pressure RVSP: right ventricular systolic pressure RV: right ventricle TR: tricuspid regurgitation TRVmax: tricuspid regurgitation velocity maximum UERD: University echocardiographic regional diploma v: velocity WHO: World Health Organization