Cytotoxicity assay and MIC against clinical isolates of DR-Mtb strains of selected compounds.
| Compound code | MIC (μg mL−1) | Cytotoxicity | |||||
|---|---|---|---|---|---|---|---|
| Mtb H37Rv ATCC 27294 | Mtb INH-resa ATCC 35822 | Mtb ETB-resa ATCC 35837 | Mtb STR-resa ATCC 35820 | Mtb RIF-resa ATCC 35838 | Vero cell CC50 (μg mL−1) | SIb | |
| 5o | 0.5 | 2 | 2 | 1 | 2 | >50 | >100 |
| 9a | 0.03 | 0.25 | 0.03 | 0.03 | 0.03 | >10 | >320 |
| 9b | 0.12 | 0.25 | 0.06 | 0.25 | 0.06 | >20 | >160 |
| 9c | 0.03 | 0.12 | 0.03 | 0.03 | 0.03 | >2.5 | >80 |
| 9d | 0.06 | 0.25 | 0.06 | 0.06 | 0.06 | >40 | >640 |
| INH | 0.03 | >64 | 0.03 | 0.03 | 0.03 | n.d. | n.d. |
| RIF | 0.06 | 0.03 | 0.03 | 0.03 | 64 | n.d. | n.d. |
| STR | 1 | 1 | 1 | >64 | 1 | n.d. | n.d. |
| ETB | 2 | 4 | 32 | 2 | 2 | n.d. | n.d. |
a
INH-res: isoniazid-resistant; ETB-res: ethambutol-resistant; STR-res: streptomycin-resistant; RIF-res: rifampicin-resistant.
b
Selectivity index = CC50/MIC; n.d.: not determined.