Table 2. Summary of various approaches to management of depression.

SSRI- selective serotonin re-uptake inhibitor, 5HT- serotonin, SERT- serotonin transporter, NE- norepinephrine, SNRI- serotonin norepinephrine reuptake inhibitor, NET- norepinephrine transporter, TCA- tricyclic antidepressants. MAOI- monoamine oxidase inhibitor, SDAM- serotonin dopamine activity modulator, 5HT1A- serotonin type 1A receptor, D2- dopamine type 2 receptor, 5HT2A-serotonin type 2A receptor, CBT- cognitive behavioral therapy, ECT- electroconvulsive therapy

Types of treatment	Mechanisms
Lifestyle Modifications	Improving quality of sleep, exercise, healthy eating, meditation, stress management, avoiding alcohol/drug use
Classes of Medications	SSRI-inhibit reuptake of 5HT by binding to SERT; SNRI-inhibit reuptake of both serotonin and NE by binding to SERT and NET and weakly inhibits dopamine reuptake; TCA-inhibit reuptake of both 5HT and NE by binding to SERT and NET, antihistamine & anticholinergic; MAOI inhibits the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and increasing their availability; SDAMs- partial agonist at 5-HT1A and D2 receptors and an inhibitor at 5-HT2A and NE alpha type 1B and type 2C receptors, with similar potencies; Atypicals - dopamine reuptake inhibitor, 5HT receptor modulator, inhibits alpha two receptors
Psychotherapy: CBT, Interpersonal and psychodynamic	It aids in the recognition and modification of negative thoughts and behaviours.
ECT	A seizure is triggered by electrical stimulation when used a few times a week for a short time and eliminates depression symptoms for a prolonged time.