Pharmacokinetic properties of PFD, compound YZQ17 in rats.
| Comp. | Mode | T 1/2 (h) | T max (h) | C max (ng mL−1) | AUC(0−t) (ng h mL−1) | AUC(0−∞) (ng h mL−1) | MRT(0−t) (h) | F% |
|---|---|---|---|---|---|---|---|---|
| YZQ17 | i.v. a | 0.694 | 0.083 | 712.46 | 700.647 | 701.170 | 0.856 | |
| p.o. b | 2.772 | 1.012 | 68.495 | 332.288 | 406.497 | 4.837 | 51% |
Dose: 2 mg kg−1.
Dose: 10 mg kg−1.