FIGURE 1.

Effects of honokiol on the viability and apoptosis of THP-1, U-937, and SKM-1 cells. (A) Chemical structure of honokiol. (B) Effects of honokiol on the viability of THP-1, U-937, and SKM-1 cells. Cells were incubated with different concentrations of honokiol for 24, 48, 72 h, then CCK-8 was added, and the absorbance at 450 nm was determined. The points represent mean ± SEM from three independent experiments. (C) Cytotoxic effect of honokiol on human PBMCs. PBMCs were incubated with different concentrations of honokiol for 24, 48, 72 h, then CCK-8 reagent was added, and the absorbance at 450 nm was determined. The points represent mean ± SEM from three independent experiments.