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. 2022 May 11;13:897791. doi: 10.3389/fphar.2022.897791

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Copyright © 2022 Lai, Sun, Zhang, Wang, Wang, Wang, Zhao, Liu, Xu, Song, Ping, Sun and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HMOX1 is a necessary molecule to induce ferroptsis in AML cells induced by honokiol. (A) The mRNA expression of HMOX-1, SLC7A11, and GPX4 after honokiol treatment, showing Honokiol increased the expression of HO-1 and SLC7A11. The statistical analysis of mRNA expression was presented as bar graphs (*, p < 0.05; **, p < 0.01). (B) Western blot results on the protein expression of HMOX-1, SLC7A11, and GPX4 in 3 cell lines. (C) HMOX1 inhibitor ZnPP rescued the ferroptosis of AML cells induced by honokiol. Compared with honokiol treatment group, the cell viability of honokiol combined with ZnPP treated group was significantly increased (**, p < 0.01).