Fig 4. The interaction between pRb and the MCPyV large T antigen is required for spontaneous tumor development in murine skin.

A) Representative images of MCPyV-Rb^WT (top) and MCPyV-Rb^ΔL (bottom) mice on the FVB/N genetic background at 6 months of age. The black arrowheads highlight two representative spontaneous skin tumors arising on the skin of MCPyV-Rb^WT mice. All photographs were taken at the same distance from each subject and therefore reflect the same magnitude. B) Pie charts indicate spontaneous tumor incidence in the skin of MCPyV-Rb^WT (top) and MCPyV-Rb^ΔL (bottom) mice on the FVB/N genetic background that developed over the course of 6 months. The number of mice in each condition is shown in parentheses.