Table 2.

CHD risk factor specific category-to-category hazard ratios (95% CI) together with p-values without and with covariate interactions and time dependence.

Risk factor	Model 1	Model 2	Model 3
Age of 42 years	1.48 (1.35 − 1.63)	1.91 (1.52 − 2.40)	1.94 (1.54 − 2.44)
Age of 48 years	p < .001	p < .001	p < .001
Age of 54 years		× Weight = 0.152	× Weight = 0.156
Age of 60 years		× S-LDL-C = 0.036	× S-LDL-C = 0.023
No family history	1.30 (1.17 − 1.44)	1.29 (1.16 − 1.43)	1.29 (1.16 − 1.43)
One with CHD	p < .001	p < .001	p < .001
Two or more with CHD
No diabetes	1.64 (1.39 − 1.92)	1.63 (1.38 − 1.91)	1.63 (1.38 − 1.91)
Borderline or diet-treated	p < .001	p < .001	p < .001
Diabetes
Never smoking	1.31 (1.19 − 1.45)	1.44 (1.23 − 1.69)	1.45 (1.23 − 1.70)
Previous smoker	p < .001	p < .001	p < .001
Current smoker		× Weight = 0.142	× Weight = 0.132
Normal weight	1.26 (1.13 − 1.42)	1.68 (1.23 − 2.29)	1.68 (1.23 − 2.30)
Overweight	p < .001	p = .001	p = .001
Obesity		× Age = 0.152	× Age 0.156
		× Smoking = 0.142	× Smoking = 0.132
Below borderline S-LDL-C	1.30 (1.18 − 1.42)	1.64 (1.29 − 2.08)	1.95 (1.43 − 2.67)
Borderline	p < .001	p < .001	p < .001
High S-LDL-C		× Age = 0.036	× Age = 0.023
			× TIME = 0.073
No hypertension	1.31 (1.16 − 1.49)	1.32 (1.16 − 1.49)	1.32 (1.17 − 1.50)
Borderline	p < .001	p < .001	p < .001
Hypertension

Notes. Study participants were free of coronary heart disease (CHD) at baseline (n = 1958). Model 1: Basic multiplicative survival model. Model 2: With covariate interactions. Model 3: With covariate interactions and time dependence. S-LDL-C: Serum low-density lipoprotein cholesterol.