Table 3.
Multivariate linear regression model for the associations between the quartiles (Qs) of inflammatory markers and serum klotho level.
| Model 1 | Model 2 | Model 3 | ||
|---|---|---|---|---|
| Uric acid | ||||
| Q2 vs Q1 | β coefficient (95% CI) | −35.79 (−52.35, −19.22) | −30.62 (−47.56, −13.68) | −29.22 (−46.12, −12.32) |
| P-value | <.001 | <.001 | <.001 | |
| Q3 vs Q1 | β coefficient (95% CI) | −65.72 (−82.32, −49.13) | −58.47 (−76.29, −40.64) | −55.30 (−73.10, −37.51) |
| P-value | <.001 | <.001 | <.001 | |
| Q4 vs Q1 | β coefficient (95% CI) | −107.13 (−123.78, −90.48) | −99.88 (−118.63, −81.14) | −96.15 (−114.87, −77.43) |
| P-value | <.001 | <.001 | <.001 | |
| CRP | ||||
| Q2 vs Q1 | β coefficient (95% CI) | −7.74 (−30.79,15.32) | −7.61 (−30.86,15.63) | −7.52 (−30.70,15.67) |
| P-value | .511 | .521 | .525 | |
| Q3 vs Q1 | β coefficient (95% CI) | −17.81 (−40.74,5.12) | −19.05 (−42.65,4.54) | −19.24 (−42.85,4.36) |
| P-value | .128 | .113 | .110 | |
| Q4 vs Q1 | β coefficient (95% CI) | −39.69 (−62.79, −16.60) | −49.53 (−74.53, −24.53) | −50.30 (−75.39, −25.22) |
| P-value | .001 | <.001 | <.001 | |
| WBC count | ||||
| Q2 vs Q1 | β coefficient (95% CI) | −34.02 (−50.64, −17.40) | −31.70 (−48.30, −15.11) | −33.14 (−49.70, −16.59) |
| P-value | <.001 | <.001 | <.001 | |
| Q3 vs Q1 | β coefficient (95% CI) | −38.51 (−55.04, −21.99) | −35.75 (−52.36, −19.13 | −37.71 (−54.34, −21.08) |
| P-value | <.001 | <.001 | <.001 | |
| Q4 vs Q1 | β coefficient (95% CI) | −56.39 (−73.16, −39.63) | −57.85 (−74.88, −40.81) | −58.43 (−75.65, −41.21) |
| P-value | <.001 | <.001 | <.001 | |
| MPV | ||||
| Q2 vs Q1 | β coefficient (95% CI) | 11.64 (−5.04,28.32) | 8.35 (−8.25,24.94) | 7.56 (−8.97,24.12) |
| P-value | .171 | .324 | .370 | |
| Q3 vs Q1 | β coefficient (95% CI) | 33.79 (17.01,50.57) | 31.02 (14.31,47.72) | 28.90 (12.24,45.56) |
| P-value | <.001 | <.001 | .001 | |
| Q4 vs Q1 | β coefficient (95% CI) | 52.94 (36.09,69.79) | 50.19 (33.39,66.99) | 46.69 (29.93,63.47) |
| P-value | <.001 | <.001 | <.001 | |
Q1: Quartile 1; Q2: Quartile 2; Q3: Quartile 3; Q4: Quartile 4; CRP: C-reactive protein; WBC count: white blood cell count; MPV: mean platelet volume.
Model 1 = unadjusted.
Model 2 = adjusted for age, gender, body mass index, and race/ethnicity.
Model 3 = Model 2 + adjusted for history of angina, coronary heart disease, diabetes mellitus, hypertension, and smoking history.