Table 1.

Roles of host restriction factors that inhibit IAV replication.

Categorization		The host restriction factors
The host restriction factors that directly inhibit IAV replication by regulating the IAV replication cycle	Attachment	B4GALNT2, SPOCK2
	Entry	CK2β, FGFR1, NCOA7, Nrf2, SPOCK2
	Endosomal fusion and release	IFITM3
	vRNPs import	BPIFA1, CK2β, MOV10, MxA, PLSCR1
	Replication	ISG20, NCL, STAT1, TRIM56, YBX3
	Proteins import	eEF1D, MxA
	Assembly of RNA polymerase	DDX21, SERTAD3
	Polymerase activity	HDAC6, hnRNP-F, ISG20 NCL, PACT, PKP2, RTF2
	Assembly of vRNPs	CypE, RBL2
	vRNPs export	SOD1
	Transcription	Mx1, RTF2, TRIM25
	mRNAs export	hnRNP A2/B1, Nup98, Rae1
	Protein synthesis	MxA, ZAPS, ZFP36L1
	Post-translational modification of proteins	HDM2, ISG15
	Degradation	CypA, Grail, p27Kip1, TRIM14, TRIM22 TRIM32, TRIM35, TRIM41, USP11, ZAPL
	Protein transport	ARHGAP21
	Assembly of virion	CyclinD3
	Budding	AnxA6, Viperin
	VLP budding	Tetherin
	Release	AnxA6
The host restriction factors that indirectly inhibit IAV replication by regulating the innate immune signaling pathways		AGO4, Dot1L, eIF4B, FBXW7, FGF2, FKBP5, GBP5, HDAC2, HDAC4, HDAC11, HERP, HIST1H1C, MCCC1, MVP, NF90, NLRC5, NMB, p27Kip1, PACT, RSK2, RTF2, S1PR1, SLFN14, SNW1, SPL, TIP60, TRIM14, TRIM35, ZMPSTE24