Table 2.

Roles of supportive host factors that promote IAV replication.

Categorization		The supportive host factors
The supportive host factors that directly promote IAV replication by regulating the IAV replication cycle	Attachment	Akt
	Entry	Akt, EGFR, FAK, FFAR2, GBA, LY6E MCOLN2, PLC-γ1, PLD2, RNASEK, SLC35A1
	Endosomal fusion and release	ACP2, CtsW, EPS8, GRK2, Itch, PEPD
	vRNPs import	ACP2, AP2M1, Hsp40, SH3GLB1
	Replication	IREF-2, JNK, PRPF8, α-actinin-4
	Polymerase activity	ANP32A, ANP32B, ATP7A, CDC25B, CHD1, CLE, CTR1, DDX17, DR1, eIF4A3, GPS1, HMGB1, PKC, PPP6C
	Assembly of vRNPs	FMRP, LYAR
	vRNPs export	CD151, CHD3, eIF4A3, Hsc70, KIF18A MLC, NOX2, Nucleolin, PRC2, RanBP3, SGK1, SK, TrkA, XPO1
	Transcription	CDK9, ERI1, RRP1B
	mRNAs export	DDX19, eIF4A3, NUP93, ZC3H11A
	Protein synthesis	eEF1G, JNK, P58IPK
	Post-translational modification of proteins	AIMP2, CNOT4, CRL4
	Protein transport	Cdc42, NUMA1, UBR4
	Assembly of virion	Cofilin-1
	Budding	Cofilin-1, F1β
	Release	NOX2, RACK1
The supportive host factors that indirectly promote IAV replication by regulating the innate immune signaling pathways		A20, AGO2, CUEDC2, DPF2, DR1, EZH2, FADD, FAT10, GLDC, GPS1, IFI44L, KHSRP, MK2, MK3, MKP5, NDRG1, NEDD4, PARP1, PGRN, PLD2, Rubicon, SK, SOCS1, SOCS3, TAP1, TRIM21, USP7, ZBTB25