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. 2022 May 19;37(1):1411–1425. doi: 10.1080/14756366.2022.2076674

Table 3.

In vitro TBK1 kinase inhibitory activity of the 15l–15w.a

Inline graphic
Compound R2 TBK1 inhibition（%）
 IC50/nM
10 μM 1 μM 100 nM 10 nM 1 nM 0.1 nM
15l graphic file with name IENZ_A_2076674_ILG0024.jpg 21.9 −0.6 −7.2 N.T.b N.T. N.T. N.T.
15m graphic file with name IENZ_A_2076674_ILG0025.jpg −11.0 −6.0 −8.9 N.T. N.T. N.T. N.T.
15n graphic file with name IENZ_A_2076674_ILG0026.jpg −12.5 −15.0 −8.9 N.T. N.T. N.T. N.T.
15o graphic file with name IENZ_A_2076674_ILG0027.jpg 23.3 −7.4 −2.7 N.T. N.T. N.T. N.T.
15p graphic file with name IENZ_A_2076674_ILG0028.jpg 41.1 37.1 30.6 32.0 N.T. N.T. N.T.
15q graphic file with name IENZ_A_2076674_ILG0029.jpg 83.9 25.5 12.7 4.5 N.T. N.T. N.T.
15r graphic file with name IENZ_A_2076674_ILG0030.jpg 56.8 5.7 10.8 −2.6 N.T. N.T. N.T.
15s graphic file with name IENZ_A_2076674_ILG0031.jpg N.T. 97.2 76.9 68.6 45.5 N.T. 6.2
15t graphic file with name IENZ_A_2076674_ILG0032.jpg N.T. 99.1 79.5 78.0 61.6 43.1 0.8
15u graphic file with name IENZ_A_2076674_ILG0033.jpg N.T. 89.6 78.1 30.0 25.1 12.1 33.3
15v graphic file with name IENZ_A_2076674_ILG0034.jpg N.T. 87.4 70.3 49.7 42.5 37.7 31.2
15w graphic file with name IENZ_A_2076674_ILG0035.jpg N.T. N.T. 27.1 10.7 N.T. N.T. N.T.
BX795   N.T. N.T. 99.6 72.9 37.7 0.18 7.1
MRT67307   N.T. N.T. 92.8 29.6 2.4 <0 28.7

aThe IC50 values are shown as the mean (nM) values from two separate experiments.

bN.T. = not tested.