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. 2022 May 25;8(21):eabn0379. doi: 10.1126/sciadv.abn0379

Fig. 1. Large1 gene transfer improves skeletal muscle function and extends survival.

Fig. 1.

(A) Experimental outline. Mice were weighed weekly; open circle, locomotor activity determined. (B and C) Spontaneous locomotion (distance) and rearing (vertical activity). Untreated, orange; treated, blue. (D to H) Forelimb grip strength (D), EDL muscle weight (E), EDL muscle CSA (F), EDL isometric tetanic force (Fo) (G), and specific isometric tetanic force (Fo/CSA) (H) (black; C57BL/6J (WT)); treated myd (myd AAV), age >60 weeks; untreated myd (myd), age 46.5 ± 6.5 weeks. (I) Percentages of Fo in mice at indicated time after ECC relative to Fo at first ECC. (J) Changes in body weight relative to weight at 35 weeks of age. (K) Survival curves of mice in the indicated treated groups. Symbols, individual mice; bars, means ± SEM. C57, black; myd, orange; myd AAV, blue.