Extended Data Fig. 8 |. Correlation between TH17/IL-17-related features and LCA metabolite abundance in HMP2.
TH17/IL-17-related genes in IBD upregulated in IBD were significantly negatively correlated with 3-oxoLCA and isoLCA (FDR-adjusted p-value < 0.25) but not the other 3 control BAs (LCA, DCA, and CDCA). Differentially expressed TH17/IL-17-related genes with at least one significant association are shown. This analysis was based on a subset of n = 71 subject-unique samples with matched metagenomic, metabolomic, and host transcriptomic profiling in the HMP2 cohort (33 CD, 21 UC, and 17 non-IBD controls, Spearman correlation with FDR adjusted p-value < 0.25). Correlations were based on residual transcript and metabolite abundance after correcting for diagnosis, consent age, and antibiotic use. See Table S8 for full results.