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. 2022 May 18;2022:1816217. doi: 10.1155/2022/1816217

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Copyright © 2022 Xiangkun Wu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ectopic expression of DLEU1 induced chondrocyte viability, degradation of ECM, and inflammation mediator secretion. (a) The expression of DLEU1 was measured by qRT-PCR analysis. (b) Ectopic expression of DLEU1 promoted cell viability in the chondrocytes using CCK-8 assay. (c) Elevated expression of DLEU1 suppressed collagen II expression in the chondrocytes. (d) The expression of aggrecan was detected by qRT-PCR assay. (e) Overexpression of DLEU1 induced ADAMTS-5 expression in the chondrocytes. (f) The expression of MMP-3 was measured by qRT-PCR assay. (g) DLEU1 overexpression promoted IL-6 expression in the chondrocytes using ELISA. (F) The expression of IL-8 was measured by ELISA. (i) The expression of TNF-α was measured by ELISA. ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001.