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. 2022 Feb 26;122(6):1317–1365. doi: 10.1007/s00421-022-04901-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Cardiac output ( $\dot{Q}$ ) as a function of oxygen flow ( $\dot{V} O_{2}$ in the figure, ${\dot{V}}_{R} O_{2}$ in the text) for various groups of subjects of different maximal oxygen consumption. Each symbol designates a group of subjects. Isopleths showing arterial-mixed-venous oxygen difference in ml of oxygen per L of blood ( $C_{a} O_{2} - C_{\bar{v}} O_{2}$ in the text) are also drawn

[Modified after Cerretelli and di Prampero (1987)]