Table 1.

Top 10 novel protein markers for ECs, PCs, and VSMCs.

Gene id	logCPM	PValue_ALL	FDR_ALL	PC vs. EC			VSMC vs. PC			VSMC vs EC			logCPM_EC	logCPM_PC	logCPM_VSMC	minFC
				logFC	Pvalue	FDR	logFC	Pvalue	FDR	logFC	Pvalue	FDR
PC
Q9WTW3:Kcne4	6.65	1.87E−50	5.61E−50	5.57	1.79E−27	5.92E−27	− 6.08	5.57E−31	1.72E−30	− 0.51	0.23	0.27	2.49	8.18	1.93	5.57
P50608:Fmod	7.15	6.75E−145	6.62E−144	5.11	3.80E−73	3.09E−72	− 5.93	1.22E−90	1.10E−89	− 0.82	6.03E−04	1.01E−03	3.48	8.67	2.71	5.11
Q60961:Laptm4a	6.09	8.94E−64	3.31E−63	4.72	5.80E−34	2.27E−33	− 5.33	1.51E−40	5.78E−40	− 0.61	0.07	0.09	2.84	7.59	2.10	4.72
Q7TQH7:Lrp10	4.66	4.4425745E−316	1.49066385E−314	4.28	5.45E−184	1.99E−182	− 4.26	1.95E−182	5.39E−181	0.02	0.86	0.88	1.80	6.10	1.84	4.26
Q8BLY1:Smoc1	5.06	3.23E−17	5.29E−17	4.09	3.61E−10	6.95E−10	− 4.61	5.49E−12	1.04E−11	− 0.52	0.37	0.42	2.39	6.51	1.35	4.09
P48025:Syk	4.13	5.18E−172	6.52E−171	3.89	3.50E−93	3.81E−92	− 4.29	8.02E−109	8.99E−108	− 0.40	0.02	0.03	1.64	5.55	1.25	3.89
Q6ZQ06:Cep162	5.75	2.69E−67	1.04E−66	3.87	4.71E−37	1.99E−36	− 4.30	1.13E−43	4.58E−43	− 0.43	0.11	0.14	3.29	7.16	2.77	3.87
P43407:Sdc2	3.05	1.71E−48	4.96E−48	5.16	4.52E−35	1.81E−34	− 3.86	7.35E−23	1.89E−22	1.30	2.71E−04	4.70E−04	− 0.78	4.49	0.56	3.86
Q91ZP6:Ndfip2	4.46	0.00E+00	0.00E+00	3.77	7.95E−225	4.25E−223	− 3.54	4.44E−203	1.40E−201	0.23	0.03	0.04	2.06	5.83	2.29	3.54
P18581:Slc7a2	5.85	9.61E−244	1.99E−242	4.55	2.07E−176	6.55E−175	− 3.37	1.10E−108	1.23E−107	1.19	3.77E−17	1.45E−16	2.67	7.24	3.87	3.37
EC
Q5ND28:Scarf1	4.85	3.85E−09	5.17E−09	− 5.36	3.62E−06	5.74E−06	− 0.02	0.98	0.98	− 5.39	3.36E−06	6.92E−06	6.36	0.10	0.07	5.39
Q8R0T6:Gpr97	7.12	1.31E−09	1.79E−09	− 5.05	1.02E−06	1.68E−06	0.25	0.77	0.79	− 4.80	2.60E−06	5.42E−06	8.62	2.90	3.03	4.80
Q8BHC0:Lyve1	6.58	1.46E−08	1.93E−08	− 4.69	5.10E−06	7.98E−06	0.10	0.91	0.91	− 4.59	7.37E−06	1.47E−05	8.05	3.06	2.27	4.59
P35330:Icam2	6.58	1.98E−31	4.30E−31	− 4.52	1.09E−19	2.91E−19	0.13	0.76	0.78	− 4.39	7.14E−19	2.90E−18	8.04	3.39	3.46	4.39
Q9Z1P7:Kank3	4.20	4.80E−84	2.32E−83	− 4.17	3.69E−52	2.12E−51	0.21	0.38	0.41	− 3.96	4.01E−48	3.66E−47	5.62	1.42	1.59	3.96
P08905:Lyz2	3.98	8.50E−29	1.76E−28	− 2.15	1.20E−11	2.43E−11	− 1.34	1.42E−05	2.09E−05	− 3.50	2.05E−25	1.01E−24	5.17	2.96	1.59	3.50
Q80UZ0:Fgd5	4.10	4.63E−48	1.34E−47	− 2.78	2.43E−26	7.79E−26	− 0.50	0.04	0.05	− 3.28	1.42E−34	9.30E−34	5.36	2.57	2.01	3.28
Q8BWF2:Gimap5	3.26	1.96E−27	3.95E−27	− 4.10	1.66E−20	4.54E−20	0.88	0.03	0.03	− 3.22	2.94E−14	9.99E−14	4.62	0.32	1.35	3.22
A6H6E2:Mmrn2	3.56	5.39E−60	1.87E−59	− 3.77	7.72E−42	3.64E−41	0.58	0.02	0.03	− 3.19	4.82E−32	2.93E−31	4.90	1.11	1.64	3.19
Q4ACU6:Shank3	5.09	3.34E−46	9.36E−46	− 2.53	2.37E−24	7.18E−24	− 0.60	0.01	0.01	− 3.13	9.00E−35	5.93E−34	6.31	3.76	3.13	3.13
VSMC
Q80TB8:Vat1l	6.51	2.39E−91	1.25E−90	0.28	0.34	0.37	5.35	2.62E−50	1.22E−49	5.63	3.93E−54	4.00E−53	2.26	2.68	8.03	5.35
P24288:Bcat1	5.72	3.08E−284	8.46E−283	− 0.82	3.28E−08	5.81E−08	5.06	1.20E−184	3.32E−183	4.24	8.03E−141	3.99E−139	2.94	2.10	7.18	4.24
Q80YF6:Upk3b	6.06	0.00E+00	0.00E+00	0.32	4.22E−05	6.30E−05	3.54	6.05547E−319	0.00E+00	3.86	9.88E−308	0.00E+00	3.57	3.89	7.43	3.54
Q9Z2F2:Oasl2	5.24	1.98239E−318	6.6969684E−317	0.55	6.68E−07	1.11E−06	3.31	3.00E−165	6.79E−164	3.86	3.21E−213	4.19E−211	2.74	3.29	6.60	3.31
P11928:Oas1a	5.00	1.19E−238	2.39E−237	− 0.10	0.39	0.42	3.34	4.45E−148	8.19E−147	3.24	1.38E−140	6.74E−139	3.07	2.97	6.32	3.24
Q91XB0:Trex1	3.57	6.63E−137	5.93E−136	4.06E−03	0.97	0.98	2.57	1.57E−86	1.32E−85	2.58	8.20E−87	1.66E−85	2.15	2.15	4.73	2.57
Q7TS74:Ckap2l	4.24	1.54E−126	1.21E−125	− 0.66	3.45E−06	5.47E−06	3.17	3.64E−94	3.34E−93	2.51	5.24E−63	6.64E−62	2.95	2.28	5.47	2.51
Q3V1H1:Ckap2	4.48	5.66E−174	7.34E−173	− 2.03	2.28E−41	1.06E−40	4.36	9.35E−152	1.82E−150	2.33	2.80E−53	2.81E−52	3.41	1.38	5.74	2.33
Q8CGE8:Ifi205	3.67	1.55E−80	7.13E−80	− 0.56	2.52E−04	3.61E−04	2.69	4.83E−62	2.78E−61	2.13	2.65E−41	2.05E−40	2.64	2.08	4.79	2.13
Q08091:Cnn1	4.91	8.67E−206	1.44E−204	− 0.68	1.15E−12	2.42E−12	2.74	1.16E−161	2.56E−160	2.06	2.63E−97	6.50E−96	3.96	3.28	6.02	2.06