Table. 1.
Demographics of study population and those who discontinued hormonal contraception (HC) due to adverse changes in mood and decreased sexual desire.
| Demographics variable (row N [%] or mean [SD]) |
Total current and previous HC users (N = 826) |
Discontinued due to changes in mood (n = 212) |
p value | Discontinued due to decreased sexual desire (n = 114) |
p value |
|---|---|---|---|---|---|
| Age | 29.0 (5.0) | 28.6 (4.8) | 0.256 | 29.1 (4.7) | 0.773 |
| Race | 0.498 | 0.509 | |||
| Asian | 46 | 9 (19.6%) | 6 (13.0%) | ||
| Black/African American | 29 | 5 (17.2%) | 4 (13.8%) | ||
| White | 694 | 181 (26.1%) | 100 (14.4%) | ||
| Other/multiracial | 57 | 17 (29.8%) | 4 (7.0%) | ||
| Ethnicity | 0.068 | 0.129 | |||
| Not Hispanic/Latino | 753 | 185 (24.6%) | 99 (13.1%) | ||
| Hispanic/Latino | 59 | 22 (37.3%) | 13 (22.0%) | ||
| Other/multiple ethnicities | 14 | 5 (35.7%) | 2 (14.3%) | ||
| Sexual orientation | 0.494 | 0.800 | |||
| Heterosexual | 653 | 161 (24.7%) | 87 (13.3%) | ||
| Bisexual | 128 | 37 (28.9%) | 21 (16.4%) | ||
| Homosexual/gay/lesbian | 16 | 4 (25.0%) | 2 (12.5%) | ||
| Other | 29 | 10 (34.5%) | 4 (13.8%) | ||
| Relationship status | 0.008 | 0.043 | |||
| In a relationship | 592 | 167 (28.2%) | 91 (15.4%) | ||
| Single | 234 | 45 (19.2%) | 23 (9.8%) | ||
| Household income | 0.917 | 0.656 | |||
| Less than $25,000 | 55 | 14 (25.5%) | 8 (14.5%) | ||
| $25,000-$75,000 | 323 | 87 (26.9%) | 47 (14.6%) | ||
| $75,000-$200,000 | 378 | 93 (24.6%) | 47 (12.4%) | ||
| $200,000 or more | 70 | 18 (25.7%) | 12 (17.1%) | ||
| Highest level of education | 0.260 | 0.288 | |||
| High school diploma or less | 111 | 31 (27.9%) | 10 (9.0%) | ||
| College degree | 404 | 111 (27.5%) | 60 (14.9%) | ||
| Master's/professional degree | 311 | 70 (22.5%) | 44 (14.1%) | ||
| History of mood disorder | 0.248 | 0.834 | |||
| Mood disorder | 300 | 84 (28.0%) | 40 (13.3%) | ||
| None | 526 | 128 (24.3%) | 74 (14.1%) | ||
| History of anxiety disorder | 0.630 | 0.265 | |||
| Anxiety disorder | 359 | 89 (24.8%) | 44 (12.3%) | ||
| None | 467 | 123 (26.3%) | 70 (15.0%) | ||
| History of Eating disorder | 0.071 | 0.567 | |||
| Eating disorder | 62 | 22 (35.5%) | 10 (16.1%) | ||
| None | 764 | 190 (24.9%) | 104 (13.6%) | ||
| History of Post-traumatic Stress Disorder | 0.558 | 1 | |||
| Post-traumatic Stress Disorder | 66 | 19 (28.8%) | 9 (13.6%) | ||
| None | 760 | 193 (25.4%) | 105 (13.8%) | ||
| Total ACE | 0.030 | 0.011 | |||
| Low ACE (0-1) | 471 | 107 (22.7%) | 52 (11.0%) | ||
| High ACE (>=2) | 355 | 105 (29.6%) | 62 (17.5%) | ||
| HC group | <0.001 | <0.001 | |||
| Current HC users | 541 | 74 (13.7%) | 38 (7.0%) | ||
| Former HC users | 285 | 138 (48.4%) | 76 (26.7%) | ||
| CESD | 9.5 (5.7) | 9.6 (5.9) | 0.568 | 9.1 (5.7) | 0.512 |
| GAD-7 | 6.5 (4.8) | 6.8 (5.0) | 0.366 | 6.9 (5.4) | 0.342 |
Variables were summarized with means and standard deviations for continuous variables and with frequencies and percentages for categorical variables overall and by side effect and outcome type. Differences were tested with two-sample t-tests and Fisher’s exact tests, as appropriate. Mood disorders consisted of Major Depressive Disorder and Bipolar Disorder. ACE – Adverse Childhood Experiences, HC – Hormonal Contraceptive, CESD – Center for Epidemiological Studies Depression Scale, GAD-7 – Generalized Anxiety Disorder-7