Table 2.

Risk ratios for discontinuation of hormonal contraception (HC) due to adverse changes in mood.

Full model with TOTAL ACE: Predictor of discontinuing HC due to changes in mood	Unadjusted Risk Ratio (95% CI)	P value	Adjusted Risk Ratio (95% CI)	p value
Age	0.99 (0.96, 1.01)	0.281	0.97 (0.95, 1.00)	0.020
Ethnicity (ref: not Hispanic/Latino)		0.081		0.045
Hispanic/Latino	1.52 (1.07, 2.16)	0.021	1.33 (1.00, 1.76)	0.052
Other/multiple ethnicities	1.45 (0.71, 2.97)	0.304	1.11 (0.83, 1.48)	0.469
Relationship status (ref: single)
In a relationships	1.47 (1.10, 1.96)	0.010	1.37 (1.06, 1.76)	0.014
Education (ref: HS diploma or less)		0.266		0.287
College degree	0.98 (0.70, 1.38)	0.925	1.27 (0.94, 1.73)	0.121
Master's/professional degree	0.81 (0.56, 1.16)	0.244	1.13 (0.79, 1.62)	0.508
History of mood disorder	1.15 (0.91, 1.46)	0.244	1.13 (0.91, 1.39)	0.263
History of eating disorder	1.43 (1.00, 2.04)	0.051	1.42 (1.10, 1.84)	0.007
Total ACE (ref: low [0-1])
High [>=2]	1.30 (1.03, 1.64)	0.025	1.10 (0.90, 1.35)	0.338

Unadjusted bivariate risk ratios are presented with 95% confidence intervals and p values. Adjusted Risk ratios were estimated using a log binomial generalized linear model with ACE group as the primary predictor and were adjusted for age, current HC use, history of mood disorder (Major Depressive Disorder or Bipolar Disorder) and for demographic variables associated with discontinuation at the level α = 0.2 or below (ethnicity, relationship status, education, history of eating disorder). ACE -Adverse Childhood Experiences, HC – Hormonal Contraceptive.