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. 2022 May 25;13(5):501. doi: 10.1038/s41419-022-04917-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The morphology of mitochondria in HepG2^shNC cells (A) and HepG2^shNFE2L1 cells (B) were detected by electron microscopy. C The oxygen consumption rate (OCR) of HepG2^shNC and HepG2^shNFE2L1 cells were measured with the Seahorse XF Cell Mito Stress Test Kit. D The HepG2^shNC and HepG2^shNFE2L1 cells were treated with 2-deoxy-D-glucose (2DG; 20 mM) or oligomycin (OM; 10 μM) for 12 h, and the content of ATP in cells were detected with an ATP assay kit. E The content of lactate in HepG2^shNC and HepG2^shNFE2L1 cells were detected with a lactic Acid assay kit. F The TPM values of ATPAF1, ATPAF2, ATP5F1A, ATP5F1B, ATP5F1C, ATP5F1D, ATP5F1E, ATP5IF1, ATP5MC1, ATP5MC2, ATP5MC3, ATP5MD, ATP5ME, ATP5MF, ATP5MG, ATP5MGL, ATP5MPL, ATP5PB, ATP5PD, ATP5PF, ATP5PO, and CLPB genes related to ATP synthesis in mitochondria in HepG2^shNC and HepG2^shNFE2L1 cells; data originated from transcriptome sequencing. G The total TPM values of genes in (F). n ≥ 3, *p < 0.05, ‘n.s.’ means ‘not significant’.