Table 1.
Selected miRNAs target mRNA and the relevant associated pathways as per IPA database.
| miRNA ID | Expr p value | Expr log ratio | mRNA symbol | Expr p value | Expr log ratio | Pathway |
|---|---|---|---|---|---|---|
| miR-4521 | 0.0542 | 2.853 | ACAA2 | 0.0034 | 0.91 | Fatty acid β-oxidation I, Glutaryl-CoA degradation, I, ketogenesis, ketolysis, super pathway of cholesterol biosynthesis |
| miR-7150 | 0.0429 | 1.805 | ||||
| miR-8066 | 0.0423 | 3.642 | ||||
| miR-4440 | 0.0136 | 2.997 | ATMIN | 0.0304 | − 0.243 | Role of CHK Proteins in cell cycle checkpoint control |
| miR-3173 | 0.0011 | 1.975 | CRABP2 | 0.0407 | 1.488 | Acute phase response, retinoid acid mediated apoptosis signalling |
| miR-374B | 0.0034 | 1.382 | ETFA | 0.0498 | 0.248 | NAD signalling pathway |
| miR-1909 | 0.0303 | − 0.548 | FZD2 | 0.0334 | − 1.057 | Adipogenesis pathway, osteoarthritis pathway, role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis, role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis |
| miR-4440 | 0.0136 | 2.997 | GHRL | 0.0388 | 0.429 | Leptin signalling in obesity |
| miR-548L | 0.0712 | 1.677 | ||||
| miR1260B | 0.0206 | 0.901 | JMJD7-PLA2G4B | 0.05 | 0.483 | ERK/MAPK signalling, glucocorticoid receptor signalling, MIF regulation of innate immunity, MIF-mediated glucocorticoid regulation, pathway, p38 MAPK signalling, phospholipase C signalling, VEGF family ligand-receptor interactions, CCR3 signalling in eosinophils |
| miR-646 | 0.0702 | 3.95 | ||||
| miR-2861 | 0.0611 | − 1.178 | LSM1 | 0.0312 | − 0.282 | Systemic lupus erythematosus signalling |
| miR-3934 | 0.0758 | 1.072 | MT-ATP6 | 0.0307 | − 0.991 | Mitochondrial dysfunction, oxidative phosphorylation, sirtuin signalling pathway, estrogen receptor signalling, glucocorticoid receptor signalling |
| miR-671 | 0.0386 | − 0.35 | ||||
| miR-3188 | 0.0358 | 1.958 | ||||
| miR-7150 | 0.0429 | 1.805 | PAIP1 | 0.0265 | − 0.209 | CSDE1 signalling pathway, EIF2 signalling, Insulin secretion signalling pathway |
| miR-3173 | 0.0611 | 1.975 | PDK4 | 0.000364 | 3.19 | Glucocorticoid receptor signalling. Reelin signalling, senescence pathway |
| miR-2861 | 0.0611 | − 1.178 | ||||
| miR-626 | 0.0446 | 1.486 | ||||
| miR-28 | 0.0429 | 2.181 | ||||
| miR-7150 | 0.0358 | 1.805 | ||||
| miR-3188 | 0.0470 | 1.958 | ||||
| miR-3934 | 0.0611 | 1.072 | ||||
| miR-1909 | 0.0303 | − 0.548 | SIGIRR | 0.0445 | 1.124 | NF-κB Signalling, TLR signalling, TREM1 signalling |
| miR-7150 | 0.0429 | 1.805 | ||||
| miR-6868-5P | 0.0025 | 1.501 | ||||
| miR-637 | 0.0063 | − 1.747 | SPCS1 | 0.00457 | − 0.389 | Insulin secretion signalling pathway |