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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: J Control Release. 2022 Feb 11;345:176–189. doi: 10.1016/j.jconrel.2022.02.011

Figure 4.

Figure 4.

Peptide/protein-based drug encapsulation methods using silk. A. Preparation of silk aqueous solutions for peptide/protein-based drug loading. B. Methods to prepare drug encapsulated silk microspheres. C. List of methods to prepare drug loaded silk nanoparticles. D. Methods for using silk hydrogels to encapsulate peptide/protein drugs. E. Method to prepare silk microneedles for encapsulating peptide/protein drugs. (adapted from Tsioris et al. (182), reproduced with permission, copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim))