Table 3.

Univariate and multivariate analyses of risk factors with and OS in the training cohort.

Variables	HR (95% CI)	P value
Univariate analyses
Age (years) (> 60 vs. ≤ 60)	1.470 (0.952, 2.270)	0.083
Gender (male vs. female)	0.851 (0.546, 1.326)	0.476
BMI	0.969 (0.928, 2.535)	0.146
Child–Pugh classification (B and C vs. A)	2.232 (0.927, 5.372)	0.073
Alcohol consumption (yes vs. no)	1.262 (0.812, 1.963)	0.302
Hepatitis B (yes vs. no)	0.284 (0.153, 0.525)	< 0.001
Hepatitis C (yes vs. no)	1.078 (0.553, 2.104)	0.825
Histologic grade (G3-4 vs. G1-2)	0.922 (0.590, 1.439)	0.720
Microvascular invasion (yes vs. no)	1.527 (0.917, 2.543)	0.103
AJCC tumor stage (III and IV vs. I and II)	3.317 (2.084, 5.278)	< 0.001
Risk score	2.714 (2.163, 3.405)	< 0.001
Multivariate analyses
Hepatitis B (yes vs. no)	0.451 (0.227, 0.894)	0.023
AJCC tumor stage (III and IV vs. I and II)	1.917 (1.154, 3.182)	0.012
Risk score	2.163 (1.670, 2.800)	< 0.001

HR, hazard ratio; CI, confidence interval; OS, overall survival; BMI, body mass index; AJCC, American Joint Committee on Cancer.