Table 4.

Univariate and multivariate analyses of risk factors with and OS in the validation cohort.

Variables	HR (95% CI)	P value
Univariate analyses
Age (years) (> 60 vs. ≤ 60)	0.923 (0.507, 1.680)	0.794
Gender (male vs. female)	0.797 (0.436, 1.458)	0.461
BMI	1.023 (0.992, 1.055)	0.145
Child–Pugh classification (B and C vs. A)	0.967 (0.286, 3.274)	0.957
Alcohol consumption (yes vs. no)	0.558 (0.245, 1.267)	0.163
Hepatitis B (yes vs. no)	0.591 (0.270, 1.292)	0.188
Hepatitis C (yes vs. no)	1.051 (0.498, 2.221)	0.896
Histologic grade (G3-4 vs. G1-2)	1.778 (0.952, 3.323)	0.071
Microvascular invasion (yes vs. no)	1.156 (0.555, 2.407)	0.698
AJCC tumor stage (III and IV vs. I and II)	1.329 (0.691, 2.554)	0.393
Risk score	1.564 (1.200, 2.037)	0.001
Multivariate analyses
AJCC tumor stage (III and IV vs. I and II)	0.569 (0.628, 2.331)	0.569
Risk score	1.756 (1.208, 2.554)	0.003

HR, hazard ratio; CI, confidence interval; OS, overall survival; BMI, body mass index; AJCC, American Joint Committee on Cancer.