Table 3.
Univariate and multivariate analyses of risk factors related to progression-free survival.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age ≥ 75 years | 1.03 (0.49–2.17) | 0.93 | 1.01 (0.45–2.25) | 0.98 |
| Gender, Male | 1.76 (0.90–3.47) | 0.10 | ||
| ECOG PS ≥ 2 | 1.75 (0.91–3.36) | 0.096 | 2.19 (1.09–4.42) | 0.028 |
| BMI ≥ 25 | 0.77 (0.27–2.17) | 0.62 | 0.66 (0.22–2.01) | 0.47 |
| Current or former smoker | 1.21 (0.47–3.11) | 0.69 | 1.23 (0.46–3.30) | 0.68 |
| Histologic type, Sq | 1.68 (0.87–3.25) | 0.12 | ||
| PD-L1 TPS ≥ 50% | 0.48 (0.25–0.93) | 0.030 | 0.45 (0.23–0.88) | 0.020 |
| Goddard score ≥ 1 | 0.41 (0.21–0.80) | 0.009 | 0.36 (0.18–0.71) | 0.004 |
| Treatment line ≥ 2 | 1.98 (1.03–3.82) | 0.041 | ||
Sq squamous cell carcinoma, ECOG PS Eastern Cooperative Oncology Group performance status, BMI body mass index, TPS tumor proportion score.