Table 4.
Univariate and multivariate analysis of risk factors related to overall survival.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age ≥ 75 years | 0.69 (0.26–1.81) | 0.45 | 0.46 (0.16–1.29) | 0.14 |
| Gender, Male | 1.57 (0.69–3.56) | 0.28 | ||
| ECOG PS ≥ 2 | 1.78 (0.82–3.86) | 0.15 | 3.62 (1.42–9.19) | 0.007 |
| BMI ≥ 25 | 0.42 (0.16–1.11) | 0.079 | 1.00 (0.32–3.09) | > 0.99 |
| Current or former smoker | 2.43 (0.57–10.26) | 0.23 | 2.78 (0.62–12.48) | 0.18 |
| Histologic type, Sq | 1.59 (0.72–3.51) | 0.25 | ||
| PD-L1 TPS ≥ 50% | 0.35 (0.16–0.75) | 0.007 | 0.26 (0.11–0.59) | 0.001 |
| Goddard score ≥ 1 | 0.52 (0.24–1.13) | 0.099 | 0.30 (0.13–0.70) | 0.005 |
| Treatment line ≥ 2 | 1.79 (0.83–3.87) | 0.14 | ||
Sq squamous cell carcinoma, ECOG PS Eastern Cooperative Oncology Group performance status, BMI body mass index, TPS tumor proportion score.