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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Exp Eye Res. 2022 Apr 4;219:109059. doi: 10.1016/j.exer.2022.109059

Figure 2.

Figure 2

The molecular interactions that enable HSV-1 entry. HSV-1's gB or gC attaches to filopodia like projections (HSPGs) from the cell surface and unilaterally moves towards cell membrane. Then, gD binds to one of its three receptors and this allows for the recruitment of the viral fusion complex (gH-gL and gB). gB then to one of its three receptors on the cell surface and conformational change occurs which mediates membrane fusion and entry into the cell. An alternate entry route is via endocytosis or phagocytosis-like uptake.