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. Author manuscript; available in PMC: 2023 May 19.
Published in final edited form as: Cell Chem Biol. 2022 Feb 28;29(5):811–823.e7. doi: 10.1016/j.chembiol.2022.02.004

Figure 5. Antibody-dependent enhancement (ADE) assays of elicited serum.

Figure 5.

Serial dilutions of pooled mouse sera were mixed with the indicated RVPs and incubated with Fcγ-receptor expressing K562 cells. Infected cells were quantified by flow cytometry. Dose-response curves for DENV1 (A), DENV2 (B) and DENV4 (C) RVPs are shown. Results are displayed relative to the maximum infectivity observed with a type-specific EDIII-reactive mAb run in parallel for each RVP. The dotted line is provided as a reference for normalization. Error bars indicate the range of duplicate technical replicates; data is representative of two independent experiments.