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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: J Control Release. 2022 Mar 14;345:306–313. doi: 10.1016/j.jconrel.2022.03.021

Fig. 5. Intratumoral injection of DAL4-LNP-IL-12 + IL-27 mRNA induces robust infiltration of immune effector cells into tumors and stimulates the production of anti-tumor signaling molecules.

Fig. 5.

(A) Flow cytometry was used for quantifying CD45+ leukocytes and its subtypes. (B-C) Intracellular staining and flow cytometry were used for quantifying IFN-γ (B) and TNF-α (C) producing T and NK cells. *P<0.05, **P<0.01 by Mann-Whitney tests.