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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Hum Mutat. 2022 May 10;43(6):659–667. doi: 10.1002/humu.24373

FIGURE 1.

FIGURE 1

Three types of genomic matchmaking to enable novel disease-gene relationship discoveries. (a) Two-sided matchmaking refers to the scenario where two or more parties have the same novel candidate gene and are trying to find each other. This type of matchmaking is facilitated by the current MME. (b) One-sided matchmaking refers to the scenario where one party has a novel candidate variant or gene and queries a database housing structured genome-wide sequencing data from undiagnosed patients. (c) Zero-sided matchmaking refers to the scenario where computer algorithms are used to identify potentially matching undiagnosed cases with rare variants in the same gene and overlapping phenotypes.