The MME currently connects eight genomic matchmaking nodes (solid lines) representing >13,520 unique genes and 120,000 cases from over 12,000 contributors in 98 countries. The MME also connects to three databases that provide additional utility to the gene discovery scientific community and these databases are considered “Connected Knowledge Sources,” or “Model Organism Nodes”, specialized MME endpoints that go beyond the initial MME design of patient-patient matchmaking. The MME is a driver project of the GA4GH and the MME has been leveraging the expertise of the GA4GH working groups for guidance on pertinent aspects of the project.