Table 3:
Association between pre-diagnosis smoking and overall survival (to 5 years) among women with ovarian cancer, by germline BRCA status: MAYO, SEARCH and validation set (MAYO/SEARCH) pooled analysis
| MAYOa | SEARCHa | Validation set pooled analysis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA carrier | BRCA non-carrier | BRCA carrier | BRCA non-carrier | BRCA carrier | BRCA non-carrier | |||||||
| N | HRa (95% CI) | N | HRa (95% CI) | pb | N | HRa (95% CI) | N | HRa (95% CI) | pb | pHR (95% CI) | pHR (95% CI) | |
| Never smoked | 115 | 1.00 | 726 | 1.00 | 0.3 | 62 | 1.00 | 425 | 1.00 | 0.6 | 1.00 | 1.00 |
| Ever smoked | 65 | 1.44 (0.88-2.36) | 445 | 1.07 (0.90-1.26) | 39 | 0.77 (0.28-2.11) | 291 | 1.13 (0.87-1.48) | 1.24 (0.73-2.09) | 1.09 (0.94-1.25) | ||
| Former | 50 | 1.34 (0.77-2.32) | 354 | 1.08 (0.91-1.30) | 27 | 0.59 (0.18-1.91) | 205 | 1.26 (0.95-1.67) | 1.06 (0.51-2.19) | 1.13 (0.97-1.31) | ||
| Current | 15 | 1.75 (0.83-3.70) | 91 | 1.00 (0.74-1.37) | 12 | 1.80 (0.35-9.31) | 86 | 0.82 (0.51-1.32) | 1.76 (0.89-3.47) | 0.94 (0.73-1.22) | ||
Abbreviations: CI = confidence interval, HR = hazard ratio, pHR = pooled hazard ratio.
a
MAYO and SEARCH models were adjusted for age, BMI, year of diagnosis and stratified by stage.
b
p-value for the interaction between the variable and BRCA status, in the model stratified by BRCA status.