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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Contemp Clin Trials. 2022 Mar 12;116:106728. doi: 10.1016/j.cct.2022.106728

Table 2.

Baseline demographic, health, and behavioral characteristics among 21,442 COSMOS participants, according to sex.

Baseline Characteristica Men (N=8776)b Women (N=12666)b
Mean age (SD), years 69.0 (6.1) 74.2 (6.0)
Age group, years, %
 60–69
 70–74
 75–79
 80–84
 ≥85

5580 (63.6)
1753 (20.0)
898 (10.2)
382 (4.4)
163 (1.9)

3644 (28.8)
4021 (31.7)
2853 (22.5)
1379 (10.9)
769 (6.1)
Hispanic/Latino, % 233 (2.8) 311 (2.6)
Race, %
 White
 Black
 Asian/Pacific Islander
 American Indian/Alaskan Native
 Multiracial/other/unknown or not reported

7940 (90.5)
392 (4.5)
254 (2.9)
19 (0.2)
171 (1.9)

11354 (89.6)
739 (5.8)
245 (1.9)
40 (0.3)
288 (2.3)
Geographic region, %
 Northeast
 Midwest/Mountain
 South
 West/Southwest

2721 (31.0)
2063 (23.5)
2596 (29.6)
1396 (15.9)

3220 (25.4)
3008 (23.7)
3555 (28.1)
2883 (22.8)
Education, %
 High school diploma/GED or less
 Attended or graduated from college
 Post-college

540 (6.2)
3348 (38.5)
4808 (55.3)

1756 (14.0)
5337 (42.6)
5433 (43.4)
Health History
Mean body mass index (SD), kg/m2 27.9 (4.7) 27.5 (5.8)
Obesity, % 2291 (26.3) 3427 (27.8)
Hypertension, % 5074 (57.9) 7349 (58.2)
Ever use of anti-hypertensive medication, % 4530 (52.3) 6687 (53.4)
Current use of cholesterol-lowering medication, % 4302 (49.2) 5103 (40.7)
Diabetes, % 1273 (14.5) 1591 (12.6)
Current use of antidiabetic medication, % 1014 (11.6) 1219 (9.6)
Parental history of premature myocardial infarction, % 1625 (20.4) 2487 (22.4)
Personal history of revascularization procedure, % 564 (6.4) 298 (2.4)
Personal history of cancer, %
 Only melanoma
 Melanoma plus non-skin cancer
 Only non-skin cancer

1346 (15.3)
342 (3.9)
59 (0.7)
945 (10.8)

2204 (17.4)
337 (2.7)
72 (0.6)
1795 (14.2)
Family history of cancer in first degree relative
 Colorectal, %
 Breast (women only, %)
 Prostate (men only, %)
 Lung, %

1384 (16.7)
NA
1548 (18.7)
1378 (16.7)

2364 (19.7)
2522 (21.1)
NA
2191 (18.4)
Behavioral characteristics and medication use
Smoking, %
 Current
 Past
 Never

415 (4.8)
3622 (41.8)
4620 (53.4)

420 (3.4)
5109 (41.0)
6945 (55.7)
Leisure-time physical activity and stair climbing, total MET hours/week, median (IQR) 20.3 (7.5, 36.9) 15.9 (4.7, 31.3)
Aspirin use in past month, % 4700 (53.8) 5679 (45.4)
Postmenopausal hormone use, % (women only)
 Current
 Past
 Never

NA
NA
NA

1021 (8.2)
6158 (49.7)
5199 (42.0)
Screening behaviors in past 10 years
 Colonoscopy/sigmoidoscopy, %
 Prostate-specific antigen test, % (men only)
 Mammogram, % (women only)

7441 (85.8)
6958 (81.3)
NA

10131 (81.7)
NA
11650 (93.4)
Dietary factors at initial screening
Calcium intake from supplements, %
 None
 ≤1200 mg/day
 >1200 mg/day

5920 (67.9)
2668 (30.6)
126 (1.5)

4997 (40.1)
6532 (52.4)
940 (7.5)
Vitamin D intake from supplements, %
 None
 ≤1000 IU/day
 >1000 IU/day

4519 (52.0)
3008 (34.6)
1166 (13.4)

3441 (27.6)
5662 (45.4)
3370 (27.0)
Current use of multivitamins, % 3208 (36.7) 5587 (44.3)
Current use of cocoa extract supplements, % 28 (0.3) 63 (0.5)
Chocolate intake
 Rarely
 Monthly
 Weekly
 Daily or more often

1442 (18.5)
1108 (14.2)
4378 (56.2)
862 (11.1)

1910 (16.0)
1815 (15.2)
6751 (56.6)
1455 (12.2)
Alcohol use, %
 Rarely
 Monthly
 Weekly
 Daily or more often

7810 (89.0)
1814 (23.2)
441 (5.6)
2762 (35.4)
2793 (35.8)

11931 (94.2)
4053 (34.0)
1021 (8.6)
4374 (36.7)
2483 (20.8)
a

Variable definitions are provided in footnotes to Table 1.

b

For categorical variables, this column contains # participants in category/% of nonmissing responses. For continuous variables, this column contains mean (standard deviation) or median (interquartile range) for nonmissing responses.