Table 1:
Baseline Characteristics
| No PVD (Exercise PVR<1.74) (n=382) |
Latent PVD (Exercise PVR≥1.74) (n=188) |
p | |
|---|---|---|---|
| Age (years) | 70.2±8.8 | 73.5±7.4 | <.001 |
| Female (n/%) | 61% (231/382) | 63% (118/188) | 0.742 |
| BMI (kg/m2) | 33±5.8 | 31.4±6.3 | 0.039 |
| Comorbidities | |||
| Hypertension | 88% (335/381) | 89% (167/187) | 0.678 |
| Diabetes | 35% (134/382) | 40% (75/188) | 0.269 |
| Chronic Obstructive Pulmonary Disease | 19% (73/382) | 21% (40/187) | 0.576 |
| Ischemic Heart Disease | 16% (59/379) | 18% (34/187) | 0.470 |
| Permanent Pacemaker | 18% (69/382) | 20% (38/188) | 0.537 |
| Atrial Fibrillation | 47% (179/382) | 66% (124/188) | <.001 |
| Atrial Flutter | 9.2% (35/380) | 14% (25/185) | 0.145 |
| Heart Failure Status | |||
| NYHA Classification | 0.562 | ||
| II | 23% (86/382) | 20% (37/188) | |
| III | 76% (289/382) | 79% (149/188) | |
| IV | 1.8% (7/382) | 1.1% (2/188) | |
| HF visits within 12 Months of Enrollment2 | 42% (150/359) | 41% (72/175) | 0.926 |
| Hospitalization for HF in the past 12 Months | 28% (99/359) | 30% (52/175) | 0.610 |
| HFpEF (EF≥50%) | 94% (358/382) | 91% (171/188) | 0.231 |
| H2FPEF Score | 5 (4, 7) | 6 (5, 8) | 0.003 |
| Resting PCWP<15 mmHg | 33% (127/382) | 20% (37/188) | <.001 |
| Medications | |||
| Loop Diuretics | 80% (306/382) | 85% (160/188) | 0.167 |
| Thiazides Only | 4.2% (16/382) | 4.3% (8/188) | 1.000 |
| Loop Diuretics and Thiazides | 3.7% (14/382) | 8.0% (15/188) | 0.041 |
| Daily Furosemide Equivalent Dose (mg)1 | 55±50 (305) | 51±54 (160) | 0.401 |
| ACE-inhibitors or ARB | 61% (234/382) | 64% (120/188) | 0.582 |
| Beta-blockers | 69% (262/382) | 74% (139/188) | 0.205 |
| MRA | 53% (203/382) | 49% (92/188) | 0.373 |
| SGLT2 inhibitors | 3.1% (12/382) | 1.6% (3/188) | 0.406 |
| Other Baseline Measurements | |||
| BNP with AF | 196 (127,301) | 248 (113,447) | 0.317 |
| BNP without AF | 79 (37,147) | 128 (65,256) | 0.133 |
| NT-Pro BNP with AF | 881 (581,1325) | 1241 (833,1846) | 0.342 |
| NT-Pro BNP without AF | 270 (137,590) | 413 (255,723) | 0.001 |
| Estimated GFR | 56.4±18.2 (373) | 55.3±17.1 (184) | 0.496 |
1
For Subjects on Loop Diuretics)
2
Hospitalization/ER visit/Acute Care Facility Visit for Heart Failure