Table 4:
Effects on Cardiac Structure and Hemodynamics
| Change in Cardiac Structure at 12 months | Shunt | Sham | p |
|---|---|---|---|
| No Latent PVD | |||
| RA volume index, ml/m2 | +7±10 (124) | +1±8 (106) | <.001 |
| RV diastolic volume index, ml/m2 | +9±11 (100) | +3±10 (92) | <.001 |
| TAPSE, cm | +0.0±0.4 (144) | −0.0±0.4 (123) | 0.254 |
| Tricuspid regurgitation severity (0–4) | +0.31±0.58 (139) | +0.06±0.55 (119) | <.001 |
| Tricuspid regurgitation velocity (m/s) | +0.18±0.46 (136) | +0.04±0.50 (110) | 0.023 |
| LA volume index, ml/m2 | +1±8 (147) | +1±9 (126) | 0.900 |
| LV end diastolic volume index, ml/m2 | −6±10 (154) | −4±13 (133) | 0.157 |
| LV ejection fraction, % | +2±5 (162) | +2±6 (138) | 0.848 |
| E/e’ ratio | +0.1±13.2 (155) | +0.1±4.7 (132) | 0.968 |
| Latent PVD | |||
| RA volume index, ml/m2 | +6±13 (52) | +3±10 (53) | 0.227 |
| RV diastolic volume index, ml/m2 | +7±12 (40) | +5±12 (40) | 0.367 |
| Tricuspid regurgitation severity (0–4) | +0.22±0.48 (62) | +0.22±0.43 (63) | 0.956 |
| Tricuspid regurgitation velocity (m/s) | +0.19±0.63 (58) | +0.06±0.47 (58) | 0.237 |
| TAPSE, cm | +0.1±0.4 (59) | +0.0±0.4 (64) | 0.366 |
| LA volume index, ml/m2 | +1±10 (63) | +2±8 (64) | 0.383 |
| LV end diastolic volume index, ml/m2 | −8±12 (61) | −2±12 (65) | 0.008 |
| LV ejection fraction, % | +2±5 (64) | +2±6 (68) | 0.481 |
| E/e’ ratio | −0.2±4.9 (63) | −0.1±4.7 (69) | 0.899 |