Table 2.

Showing correlations between complement genes of the classical, lectin, alternative, and terminal pathways and clinical DAS28-ESR in the synovium and blood from ERA patients

	Synovium			Blood
Complement Gene	Spearman Correlation ρ	p-value	FDR1 adjusted p-value	Spearman Correlation ρ	p-value	FDR1 adjusted p-value
C1qA	0.19	0.084	0.17	0.074	0.58	0.82
C2	0.34	0.0017*	0.023*	0.035	0.79	0.87
C4B	0.18	0.099	0.19	−0.20	0.12	0.68
MBL2	0.22	0.047*	0.13	Not detected
FCN1	0.36	0.00089*	0.018*	0.055	0.68	0.84
FCN2	−0.085	0.45	0.39	0.052	0.69	0.84
FCN3	0.28	0.011*	0.06	0.081	0.54	0.81
Colec12	−0.36	0.0011*	0.02*	0.0023	0.99	0.89
C3	0.018	0.87	0.53	−0.055	0.68	0.84
CFB	0.29	0.0085*	0.052	0.097	0.46	0.80
CFD	−0.19	0.082	0.17	−0.094	0.48	0.81
CFP	0.26	0.017*	0.075	0.047	0.73	0.85
C5	−0.36	0.00097*	0.019*	0.16	0.22	0.74
C6	−0.42	0.00009*	0.0061*	Not detected
C7	−0.26	0.02*	0.084	0.036	0.78	0.86
C8A	0.082	0.47	0.39	−0.059	0.66	0.83
C9	−0.091	0.42	0.37	−0.00023	1.00	0.89

Spearman correlation (ρ) is shown between complement gene expression related to three pathways of the complement system (i.e., CP, LP, AP) and clinical DAS28-ESR (disease level) in three different pathotypes (i.e., lymphoid, myeloid, and fibroid) of the synovium (histology) and peripheral blood in a large cohort of early treatment-naïve patients, namely, the Pathobiology of Early Arthritis Cohort (PEAC) (n=90),

^*p<0.05 considered significant,

¹FDR=false discovery rate