Table 3.

Showing correlations between complement receptors, proteases, and inhibitory proteins of the complement system and DAS28-ESR in ERA patients

	Synovium			Blood
Complement Gene	Spearman Correlation ρ	p-value	FDR1 adjusted p-value	Spearman Correlation ρ	p-value	FDR1 adjusted p-value
C3AR1	0.33	0.0027*	0.03*	0.19	0.16	0.70
C5AR1	0.38	0.00045*	0.013*	0.19	0.14	0.69
CD35 (CR1)	0.44	0.000047*	0.0044*	0.38	0.0031*	0.44
CD21 (CR2)	0.20	0.066	0.16	−0.18	0.17	0.71
MASP1	−0.44	0.000035*	0.0042*	0.14	0.30	0.75
MASP2	−0.15	0.17	0.25	−0.12	0.35	0.77
CFH	−0.39	0.00037*	0.012*	0.16	0.22	0.74
CFHR1	0.13	0.26	0.30	−0.08	0.55	0.81
CFHR3	0.052	0.64	0.46	0.18	0.17	0.71
CFHR4	0.14	0.23	0.28	−0.095	0.47	0.81
CFHR5	0.12	0.29	0.31	Not detected
CD55 (DAF)	−0.14	0.20	0.27	0.13	0.33	0.76
CD46 (MCP)	−0.31	0.0044*	0.038*	0.22	0.089	0.66
CD59	−0.013	0.91	0.54	0.32	0.015*	0.51

Spearman correlation (ρ) is shown between gene expression of the complement system receptors, proteases, and inhibitory proteins and DAS28-ESR (disease level) in three different pathotypes (i.e., lymphoid, myeloid, and fibroid) of the synovium (histology) and peripheral blood in a large cohort of early treatment-naïve patients, namely, the Pathobiology of Early Arthritis Cohort (PEAC) (n=90).

^*p<0.05 considered significant,

¹FDR=false discovery rate