. Author manuscript; available in PMC: 2022 Dec 1.

Published in final edited form as: J Immunol. 2022 May 2;208(11):2482–2496. doi: 10.4049/jimmunol.2101170

Table 4.

Showing correlations between various immunoglobulin receptors and clinical DAS28-ESR in ERA

	Synovium				Blood
FcγR gene	Cluster Designation	Spearman Correlation ρ	p-value	FDR¹ adjusted p-value	Spearman Correlation ρ	p-value	FDR¹ adjusted p-value
FcγR1A ²	CD64	0.41	0.00012^*	0.0069^*	0.29	0.024^*	0.56
FcγR1B ²		0.40	0.00018^*	0.0085^*	0.32	0.014^*	0.51
FcγR2A ³	CD32	0.33	0.0023^*	0.027^*	0.34	0.0084^*	0.48
FcγR2B ³		0.14	0.20	0.27	0.17	0.19	0.73
FcγR3A ⁴	CD16	0.31	0.0044^*	0.037^*	0.26	0.048^*	0.61
FcγR3B ⁴		0.25	0.024^*	0.092	0.24	0.065	0.63

Spearman correlation (ρ) is shown between immunoglobulin gene expression and DAS28-ESR (disease level) in all parameters related to the synovium (histology) and peripheral blood in a large cohort of early treatment-naïve patients, namely, the Pathobiology of Early Arthritis Cohort (PEAC) (n=90).

p<0.05 considered significant,

FDR=false discovery rate,

Fc-gamma receptor I,

Fc-gamma receptor II,

⁴

Fc-gamma receptor III