Table 5.
Characteristics of ERA1 Synovial Biopsy Patients
| Synovial Biopsy N | Sex | Age | Meet ACR RA Criteria2 | Anti-CCP3 | RF4 | Synovial Hypertrophy Score | Power Doppler Score | Joint Site of Biopsy | Tissue Pathology | DAS285-ESR | DAS285-CRP |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | F | 24 | Yes | Negative | Negative | 3 | NA7 | Right Knee | Lymphoid | 6.33 | 5.45 |
| 2. | F | 73 | Yes | Positive | Positive | 2 | 1 | Right Knee | Diffuse | 7.75 | 5.94 |
| 3. | F | 39 | Yes | Positive | Positive | 2 | 2 | Left MCP6 | Pauci-immune | 5.78 | 4.42 |
| 4. | M | 49 | Yes | Positive | Negative | 1 | 2 | Right Wrist | NA | NA | 4.00 |
| 5. | M | 55 | Yes | Positive | Positive | 2 | 2 | Left Wrist | Lymphoid | 4.94 | 3.58 |
| 6. | M | 69 | Yes | Negative | Negative | 2 | 2 | Left Knee | NA | 5.06 | 5.61 |
| 7. | M | 57 | Yes | Positive | Positive | 3 | 1 | Right Knee | NA | 4.87 | 3.88 |
| 8. | F | 52 | Yes | Negative | Negative | 2 | 0 | Right Knee | NA | 6.54 | 4.70 |
| 9. | M | 50 | No | Negative | Negative | 2 | 0 | Right Knee | NA | NA | 2.64 |
| 10. | M | 51 | Yes | Positive | Positive | 3 | 2 | Right Knee | NA | 5.37 | 4.82 |
| 11. | F | 58 | Yes | Positive | Positive | 3 | 2 | Right Knee | NA | 4.04 | 2.73 |
| 12. | F | 54 | Yes | Positive | Positive | 2 | 2 | Left Ankle | Lymphoid | 4.15 | 2.65 |
| 13. | M | 61 | Yes | Positive | Negative | 1 | 0 | Left Ankle | Diffuse | 5.98 | 4.28 |
| 14. | F | 30 | Yes | Positive | Positive | 2 | 0 | Right Knee | Lymphoid | 7.66 | 6.52 |
| 15. | F | 68 | Yes | Negative | Positive | 1 | 0 | Left Knee | Diffuse | 6.18 | 4.57 |
| 16. | F | 44 | Yes | Negative | Negative | 2 | 0 | Right Knee | Pauci-immune | 6.20 | 5.66 |
| 17. | F | 36 | NA | Negative | Positive | 2 | 0 | Left Knee | Diffuse | 5.69 | 3.46 |
| 18. | F | 55 | Yes | Negative | Positive | 3 | 2 | Left MCP | Pauci-immune | 6.83 | 5.05 |
| 19. | F | 68 | Yes | Negative | Negative | 2 | 0 | Left Knee | Lymphoid | 4.25 | 3.52 |
| 20. | F | 30 | NA | Positive | Positive | 2 | 1 | Left Knee | Lymphoid | 5.30 | 3.90 |
| 21. | M | 39 | Yes | Positive | Positive | 2 | 2 | Right Wrist | Lymphoid | 4.53 | 4.64 |
| 22. | F | 54 | Yes | Positive | Positive | 2 | 1 | Right Wrist | NA | 5.76 | 4.26 |
| 23. | M | 46 | Yes | Positive | Positive | 2 | 2 | Left Wrist | NA | 6.11 | 4.83 |
1
ERA subjects are ≤14 months from diagnosis at time of biopsy,
2
American College of Rheumatology 1987 and/or 2010 Rheumatoid Arthritis criteria,
3
Anti-cyclic citrullinated peptide: including anti-CCP2, anti-CCP3, and anti-CCP3.1,
4
Rheumatoid Factor,
5
Disease activity score calculated using 3 variables: tender joint count, swollen joint count, and erythrocyte sedimentation rate (mm/hr) or C-reactive protein (mg/l),
6
metacarpophalangeal joint,
7
data not available