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Representation of chronic effects of neurostimulation (A) In established epilepsy, seizure suppression (shaded region) temporarily reduces the probability of seizures, with no permanent effect on disease state of epilepsy. (B) In established epilepsy, disease modification (shaded region) results in permanent reduction in seizure frequency, ideally resulting in seizure freedom or “cure”, even after stimulation is stopped. The black bar represent the time period of stimulation.
