Table 3.

Associations of single htSNP in TP53 and CD3EAP rs735482 with lung cancer risk^a,b.

Gene/rs	Co-dominant	Dominant	Recessive	Log-additive
Ca/Co	(AB vs AA)/(BB vs AA)/p	(AB+BB vs AA)/p	(BB vs AA+AB)/p	- -/p
TP53
rs12951053 (A>C)
509/516	0.97 (0.74–1.26)/0.91 (0.59–1.41)/0.91	0.96 (0.74–1.23)/0.73	0.93 (0.61–1.40)/0.72	0.96 (0.79–1.16)/0.67
rs1042522 (G>C)
489/489	1.03 (0.77–1.38)/1.00 (0.69–1.44)/0.97	1.02 (0.77–1.35)/0.89	0.98 (0.71–1.34)/0.90	1.00 (0.84–1.20)/0.99
rs8079544 (C>T)
509/516	1.03 (0.73–1.45)/2.57 (0.23–28.86)/0.72	1.05 (0.74–1.47)/0.80	2.56 (0.23–28.73)/0.43	1.06 (0.76–1.48)/0.72
rs12602273(C>G)
509/516	0.94 (0.72–1.23)/0.69 (0.43–1.10)/0.30	0.89 (0.69–1.15)/0.37	0.70 (0.44–1.12)/0.13	0.88 (0.72–1.06)/0.18
rs8064946 (G>C)
509/516	0.92 (0.71–1.19)/0.68 (0.44–1.06)/0.23	0.87 (0.68–1.12)/0.27	0.71 (0.46–1.09)/0.11	0.86 (0.71–1.04)/0.12
CD3EAP
rs735482 (A>C)
522/511	1.15 (0.86–1.54)/1.25 (0.88–1.78)/0.43	1.18 (0.90–1.55)/0.23	1.15 (0.85–1.55)/0.37	1.12 (0.94–1.33)/0.20

^aDominant model: AB (Heterozygote) + BB (Homozygous variant-type) versus AA (Homozygous wild-type), Recessive model: BB versus AA+AB. Co-dominant model: AB versus AA and BB versus AA, Log-additive model: Analysis of trend where AA is ‘0’, AB is ‘1’ and BB is ‘2’.

^bOR (95% CI), adjusted for smoking duration.