Table 4.

Association of TP53 htSNP haplotypes with lung cancer risk^a.

Number	Haplotypeb	Case frequency	Control frequency	OR (95% CI)	p value
1	AGCCG	0.5071	0.4753	1.0	–
2	CCCGC	0.2237	0.2210	0.96 (0.77–1.21)	0.75
3	ACTCG	0.0754	0.0632	1.11 (0.77–1.61)	0.58
4	CCCCG	0.0572	0.0560	0.96 (0.63–1.47)	0.86
5	ACCCG	0.0432	0.0469	0.93 (0.59–1.44)	0.73
6	CCCCC	0.0404	0.0333	1.11 (0.66–1.87)	0.68
7	AGCGC	0.0160	0.0163	1.05 (0.47–2.34)	0.90
8	CGCCG	0.0128	0.0103	1.17 (0.42–3.22)	0.76
9	ACCGC	0.0003	0.0197	0.13 (0.03–0.59)c	0.0079c
10	Rare	0.0240	0.0580	0.36 (0.21–0.64)c	0.0005c

^aAdjusted by smoking duration, Global haplotype association p-value = 0.0011.

^bSNP order: rs12951053-rs1042522-rs8079544-rs12602273-rs8064946.

^cBoldface means association with decreased risk of lung cancer.