Table 6.

The best candidate models for smoking duration-gene-gene interactions from MDR analysis^a.

Model	Attribute included	Bal. ACC. Overall	Bal. ACC. CV Training	Bal. ACC. CV Testing	CV consistency	p valueb
Whole group
One-way	Smoking	0.5871	0.5872	0.5807	10/10	< 0.001c
Two-way	Smoking
	rs735482	0.6011	0.6012	0.5930	9/10	<0.001c
Three-way	Smoking
	rs967591
	rs8064946	0.6174	0.6204	0.5678	6/10	0.006–0.007c
Four-way	Smoking
	rs1970764
	rs735482
	rs1042522	0.6509	0.6572	0.5294	8/10	0.347–0.348
Histology subgroup
Squamous cell carcinoma
One-way	Smoking	0.6466	0.6471	0.6366	10/10	<0.001c
Two-way	Smoking
	rs967591	0.6626	0.6627	0.6555	9/10	<0.001c
Three-way	Smoking
	rs967591
	rs1042522	0.6877	0.6907	0.6323	7/10	<0.001c
Four-way	Smoking
	rs1970764
	rs1042522
	rs8064946	0.7159	0.7257	0.5778	4/10	0.018–0.019c
Adenocarcinoma
One-way	rs967591	0.5476	0.5483	0.5283	10/10	0.475–0.476
Two-way	rs967591
	rs12951053	0.5751	0.5763	0.5237	6/10	0.536–0.537
Three-way	rs1970764
	rs735482
	rs1042522	0.61	0.6131	0.5246	5/10	0.529–0.53
Four-way	rs1970764
	rs735482
	rs12951053
	rs1042522	0.6627	0.6686	0.5194	5/10	0.6–0.601
Other
One-way	Smoking	0.5931	0.5931	0.5931	10/10	0.073–0.074
Two-way	Smoking
	rs967591	0.6449	0.6472	0.6009	9/10	0.05–0.051
Three-way	Smoking
	rs967591
	rs1042522	0.692	0.696	0.6	9/10	0.053–0.054
Four-way	Smoking
	rs1970764
	rs735482
	rs1042522	0.7552	0.763	0.5349	10/10	0.566–0.567

^aAnalyzed by MDR 3.0.3. dev. Jar, data for PPP1R13L and CD3EAP from previous reports [17].

^bp value based on 1000 permutation test.

^cBoldface means statistical significance.